Fondaparinux reversal with activated prothrombin complex concentrate in anesthetised bleeding rats.
نویسندگان
چکیده
Gilles Corbonnois1,2*; Michèle Martin2,3*; Marie Hacquard3; Bruno Levy2,4; Paul Michel Mertes1,2; Thomas Lecompte2,3,5**; Gérard Audibert1,2** 1University Hospital of Nancy, Department of Anaesthesia and Intensive Care Medicine, Nancy, France; 2INSERM 961, Contrat Avenir INSERM, Nancy, France; 3University Hospital of Nancy, Haematology Laboratory – Haemostasis, Nancy, France; 4Hospital University of Nancy, Intensive Care Medicine, Nancy, France; 5 Present address: Hôpitaux Universitaires de Genève, Service d’hématologie, Département académique de Médecine Interne, Faculté de médecine, UniGe, Genève, Switzerland
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Fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC) reverse oral anticoagulants such as Warfarin. We compared the standard dosage FFP and PCC in terms of efficacy and safety for patients with mechanical heart valves undergoing interventional procedures while receiving Warfarin. Fifty patients were randomized (25 for each group) with mechanical heart valves [international normali...
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ورودعنوان ژورنال:
- Thrombosis and haemostasis
دوره 109 3 شماره
صفحات -
تاریخ انتشار 2013